Senior Scientist, Biology & Translational Sciences

Description

About TRIANA Biomedicines: 

TRIANA Biomedicines is a Greater Boston biotechnology company building the leading molecular glue discovery platform to regulate disease targets that are difficult to address with any other modality. TRIANA’s drug discovery engine is powered by high-resolution structural insights, state-of-the-art AI and computational tools, and bespoke chemical libraries. 

TRIANA’s target-first and rational approach to molecular glue discovery is currently focused on inducing or enhancing the degradation of high-profile cancer targets. The therapeutic approach pioneered by TRIANA has the potential to fundamentally change the paradigm of small molecule drug discovery and bring significant therapeutic benefits to patients. TRIANA is a private company with a top-tier investor syndicate.

We are seeking an experienced immunologist with deep in vitro and in vivo pharmacology expertise to join our Biology and Translational Sciences group. This role is central to advancing discovery programs from hit validation on by establishing clear mechanistic and translational links between target degradation and disease-relevant immunological outcomes in autoimmune and inflammatory disease.

We are looking for a scientifically rigorous, highly accountable individual who thrives in a fast-paced biotech environment and is motivated by generating decisive data that drives program progression.

Responsibilities:

• Assay Development: Design, develop and implement robust disease relevant cell-based assays to assess target engagement, protein degradation, and downstream pathway modulation.

• Mechanistic Biology: Design and execute experiments that connect target degradation to phenotypic response in primary human immune cells and in validated in vivo models of autoimmune disease.

• In Vivo Pharmacology: Design, manage and interpret in vivo studies conducted with external partners in rodent models of autoimmune and inflammatory disease (e.g., rheumatoid arthritis), including PK/PD and efficacy studies, and translate target degradation and pharmacodynamic readouts into disease-relevant endpoints.

• Data Generation & Interpretation: Identify critical project questions and produce high-quality, actionable datasets that guide stage-appropriate program decisions.

• Collaboration and Communication: Distill complex biological data into clear insights and communicate findings effectively to cross-functional partners and leadership; maintain thorough and accurate experimental documentation.

Education & Experience

• Ph.D. in Immunology, Immunobiology, or a related discipline with 6+ years of post-graduate experience (industry experience preferred) or B.S./M.S. with 12+ years of industry experience.

• We welcome applications from skilled individuals whose qualifications may not fit the criteria outlined above.

• Base Salary Range: $130-$145k

Our Culture

Our Team is our greatest asset at TRIANA. We are proud to work with an integrated group of individuals from an extensive range of backgrounds and experiences. Diversity, Equity, Inclusion and Belonging are important aspects of our culture. We embrace our differences and cultivate an environment that drives better collaboration and innovation by striving to ensure that all coworkers have an ongoing positive experience while being their authentic selves.

Our Values

At TRIANA we are empowered to act. We dare to create transformative medicines for patients. Our creativity and dedication are the glue that unites us in pursuit of our mission.

Thank you for your interest in TRIANA!

Qualifying candidates should apply here

TRIANA Biomedicines is an Equal Opportunity Employer take great pride in creating a diverse employment environment.

TRIANA Biomedicines does not accept unsolicited resumes from search firms for listed employment opportunities. All unsolicited resumes/CVs submitted through our website or to personal e-mail accounts of employees of TRIANA shall be deemed property of TRIANA. TRIANA explicitly reserves the right to pursue and hire those candidates without any financial obligation to the recruiter or search firm.