Senior Director, Clinical Science

Description

About TRIANA Biomedicines: 

TRIANA Biomedicines is a Greater Boston biotechnology company building the leading molecular glue discovery platform to regulate disease targets that are difficult to address with any other modality. TRIANA’s drug discovery engine is powered by high-resolution structural insights, state-of-the-art AI and computational tools, and bespoke chemical libraries. TRIANA’s target-first and rational approach to molecular glue discovery is currently focused on inducing or enhancing the degradation of high-profile cancer targets. The therapeutic approach pioneered by TRIANA has the potential to fundamentally change the paradigm of small molecule drug discovery and bring significant therapeutic benefits to patients.  TRIANA is a private company with a top-tier investor syndicate.  

Role: 

The Senior Director, Clinical Science will provide strategic leadership and scientific expertise to support the clinical development of drug candidates across all phases. This individual will participate in the design, execution, and interpretation of clinical trials, collaborating closely with cross-functional teams including but not limited to Clinical Operations, Regulatory Affairs, Translational, Biostatistics, Safety and Finance. The ideal candidate will be a hands-on scientific leader with deep experience in clinical trial design, a passion for innovation, and a strong understanding of regulatory and clinical landscapes.

Responsibilities:

• Serve as the scientific lead for clinical programs, ensuring the generation of high-quality clinical data to support regulatory submissions.

• Develop and refine clinical development plans in collaboration with internal stakeholders and external advisors.

• Provide clinical and scientific leadership for protocol development, clinical study reports, and other regulatory documents (e.g., INDs, NDAs, briefing books).

• Interpret clinical data and prepare summaries for internal decision-making and external communications.

• Partner with Clinical Operations to ensure studies are executed on time, within budget, and in compliance with GCP and regulatory requirements.

• Support regulatory interactions, including preparation for meetings with health authorities (e.g., FDA, EMA).

• Represent Clinical Science in cross-functional development teams, advisory boards, and scientific meetings.

• Lead or mentor future junior clinical scientists and/or direct reports as applicable.

• Collaborate with Key Opinion Leaders (KOLs) and contribute to the development of publications and presentations.

Qualifications:

• Advanced degree (PhD, MD, PharmD or equivalent) in life sciences or related field is required.

• Minimum of 10+ years of experience in clinical development within the biopharmaceutical industry, with at least 5 years in a leadership role.

• Strong track record of success in designing and executing clinical trials in oncology.

• Experience in US/EU (mandatory) and Asia (South Korea/Japan/China) (preferred).

• In-depth knowledge of drug development, clinical trial methodology, regulatory requirements (e.g., ICH, GCP), and relevant disease indications.

• Proven ability to analyze complex data and provide clear, strategic insights.

• Superior communication skills supporting productive interactions with physicians and regulators.

• Excellent written and verbal communication skills.

• Ability to work effectively in a fast-paced, collaborative, and matrixed environment.

• Experience with both early-phase (FIH) and later-stages of clinical programs (preferred, not mandatory).

• Experience supporting regulatory submissions (e.g., NDA/BLA) (not mandatory).

• Demonstrated ability to mentor teams.

We welcome applications from skilled individuals whose qualifications may not fit the criteria outlined above. 

Our Culture: 

Our Team is our greatest asset at TRIANA. We are proud to work with an integrated group of individuals from an extensive range of backgrounds and experiences. Diversity, Equity, Inclusion and Belonging are important aspects of our culture. We embrace our differences and cultivate an environment that drives better collaboration and innovation by striving to ensure that all coworkers have an ongoing positive experience while being their authentic selves. 

Our Values: 

At TRIANA we are empowered to act. We dare to create transformative medicines for patients. Our creativity and dedication are the glue that unites us in pursuit of our mission. 

Thank you for your interest in TRIANA!

Qualifying candidates should apply here

TRIANA Biomedicines is an Equal Opportunity Employer take great pride in creating a diverse employment environment.

TRIANA Biomedicines does not accept unsolicited resumes from search firms for listed employment opportunities. All unsolicited resumes/CVs submitted through our website or to personal e-mail accounts of employees of TRIANA shall be deemed property of TRIANA. TRIANA explicitly reserves the right to pursue and hire those candidates without any financial obligation to the recruiter or search firm.