Our Science

Transformational Paradigm in Targeted Protein Degradation (TPD)

We are harnessing diverse E3 ligases to destroy challenging disease targets at the source.

The Best Modality for Targeted Protein Degradation

Molecular glue degraders eliminate disease-causing proteins by promoting their interaction with the cell’s ubiquitin-proteasome system, a highly regulated pathway that eliminates unwanted proteins.

Specifically, molecular glue degraders enhance the binding between a disease-causing protein and an E3 ligase, even if these proteins do not normally interact.

Unlike traditional inhibitors, which typically block the activity of a disease-causing protein, molecular glue degraders can eliminate the target protein itself, offering the potential for a more complete and sustained therapeutic effect.

Triana's Discovery Platform

Transforming Targeted Protein Degradation

Our target-first and rational approach to molecular glue discovery enables us to consider a wide range of therapeutic applications for our products. Our drug discovery efforts are advanced with emphasis on known disease-causing protein targets.

  • Start with the Right Disease Targets

    We begin by selecting disease targets that are key drivers of disease, prioritizing high-value therapeutic targets that remain inadequately addressed by conventional drug modalities. By integrating genomic, functional, and translational data, we identify disease targets with the greatest therapeutic potential.

  • Match the Optimal E3 Ligase

    Our proprietary platform matches the selected disease target with preferred E3 ligases that have the potential to lead to target degradation. This rational strategy provides the biological foundation for molecular glue degrader discovery.

  • Proximity-First Molecular Glue Discovery

    We systematically identify small molecules that promote the interaction between a disease target and its matched E3 ligase. This prospective approach enables efficient exploration of diverse chemical space to discover novel molecular glue degraders.

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Protein:Protein Pairing Engine

We are using a multilayered approach, inclusive of artificial intelligence as well as experimental approaches to prioritize a short list of E3 ligases out of the entire universe of greater than 600 E3 ligases.

Bespoke Molecular Glue Libraries

Molecular glues come in all shapes and sizes. We explore a wide range of chemical spaces to discover novel molecular glues.

Structure-Guided Optimization

We use advanced structural biology techniques and proprietary structures to optimize our molecular glues.

Publications

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